STAY AHEAD OF CANCER
HBOC is hereditary, meaning that it is caused by a mutation (genetic change) that can be passed down in families. A genetic test can help determine if your personal or family history of cancer was caused by HBOC. If you are found to have HBOC, there are interventions that can help prevent cancer or detect it early.
Genetic testing and cancer
If you have a BRCA mutation, you are much more likely to get certain cancers:
- Up to a 65% risk (about 6 out of 10) for breast cancer by age 70
- Up to a 39% risk (about 4 out of 10) for ovarian cancer by age 70
- Increased risks for other cancers including prostate, pancreatic, and male breast cancers
Genetic testing and cancer
Half of all men and one-third of all women in the US will develop cancer during their lifetimes.¹
In many cases, a person’s genetics has made them more susceptible to cancer—and, as a result, they may respond differently to therapies, benefit from more aggressive treatment, or take action to avoid getting cancer again in the future.
1 in 8 patients
with cancer has a gene mutation passed down through their family
One-third of patients with high-risk mutations could benefit from different, more tailored cancer treatment after genetic testing
Forewarned is forearmed
If you are found to have HBOC, steps can be taken to reduce your cancer risks, including:
- Having earlier, more frequent, and/or additional cancer screenings
- Taking medications that can decrease the risk of cancer
- Undergoing preventive surgery to remove your breasts, ovaries, and fallopian tubes
Your genes can be an important tool for managing cancer
Discovering that you have a genetic mutation means that your family members may also be at risk. They can get tested too and, if they also have the genetic change, can get more frequent cancer screenings so they can act early, when treatment is most effective.
Why is it important ?
By 2025, over 2,00,000 cases of breast cancer and nearly 50,000 cases of ovarian cancer are estimated to be reported annually in India. For women in India there is a 8-12% risk of developing breast cancer and 1.2% risk of developing Ovarian cancer (inclusive of hereditary mutations and non hereditary causes) 6% of breast cancers and 10-20% of ovarian cancers are caused by inherited mutations in the BRCA1 & BRCA2 genes.
As per NCCN/GeneReviews, for BRCA1 mutation carriers, the risk for breast cancer is upto 72% and that for ovarian cancer is up to 58%. For BRCA2 mutation carriers, the risk for breast cancer is upto 69% and that for ovarian cancer, it is upto 29%. The chances of developing breast cancer increase significantly after the age of 35-40 years.
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